Manipulating micro objects has become an important task in several applications. Actuation is a crucial aspect of micromanipulation because there are physical restrictions which affect actuators’ performances at the micro or nano scale. One way of getting rid of these limitations is the use of an appropriate mechanical structure which enhances the elasticity of the material or provides mechanical advantage.

This Special Issue of Actuators, which is dedicated to micromanipulation, offers a contribution to the development of some promising methods to actuate a microsystem for micromanipulation.